Decoding antiviral immunity, emerging viruses and zoonoses, and designing next‑generation therapies.

At the Bamford Lab we study how humans and animals sense, fight and control viral infection, from the interferons of the innate immune response to the RNA viruses that jump between species and spark new epidemics. Taking a One Health perspective, and drawing on all we learned through the COVID-19 pandemic, we track emerging and zoonotic threats and unite virology, evolution and drug design with deep learning and AI to turn that understanding into new ways to stop disease.

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Bamford Lab, Antiviral Immunity

Research

Antiviral immunity is our central question: how cells and animals sense viral infection, switch on the interferon response, and keep that defence in balance, especially at the mucosal surfaces where infection begins and against the RNA viruses that jump between species. What makes the lab distinctive is that we pursue it from four directions at once.

Virology

Hands-on molecular virology of the RNA viruses that jump between species: how they infect cells, replicate, and trigger or evade the immune response.

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Evolutionary biology

Reading the evolutionary arms race between hosts and viruses to understand where immunity came from and where it is going.

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AI and computational biology

Deep learning and evolutionary data to decode immune signalling in infection, inflammation and cancer, and to inform the design of new therapeutics.

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Drug design

Turning discoveries about immune defence into new antivirals and strategies to strengthen the body's own response to infection.

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Explore all our research
The Bamford Lab at Queen's University Belfast

A multidisciplinary team decoding viruses and immunity

Virologists and immunologists working alongside evolutionary and computational biologists, led by Dr Connor Bamford.

Meet the lab

Lab news

Grants, papers, conferences, new starters and lab life. The three latest show here; the full history lives on the news page.

November 2026

Talk and posters at the Microbiology Society Annual Meeting in Ireland

James gave a talk, "Integrating evolutionary biology and deep learning to uncover selective druggable targets in virally targeted immune signalling", and Mollie, Jiaying and Banbha presented posters on viruses of nematodes, pollution and pathogens in wild otters, and tick-borne flaviviruses in Northern Ireland. Photos on the people page.

November 2026

Emer McCann joins as our first postdoc

Emer joins us as a Research Fellow on EnviroFlu, surveilling avian influenza in freshwater sites used by wild migratory waterbirds across the island of Ireland. Meet Emer.

October 2026

Talks in Glasgow and Belfast

Connor and Kaitlin both spoke at the IFN-λ Satellite Workshop, held at the CRUK Scotland Institute in Glasgow on 22 October as a satellite to Cytokines 2026, on interferon-lambda evolution and on species-specific restriction of interferon-lambda activity across mammals. The day before, James gave a talk at the NILAB Annual Symposium titled "Predicting where protein language models are evolutionarily blind". Photos on the people page.

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Publications

2026
Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium.
McCabe M, Groves HE, Getty E, Campbell E, Bamford CGG, Courtney DG, Lopez Campos G, Shields MD, Power UF.
Journal of Virology. 100(6):e0057825. doi:10.1128/jvi.00578-25
2025
Preclinical screening platform identifies azatadine-dimaleate as a potent repurposed therapeutic against SARS-CoV-2 infection.
Ali A, Courtney D, Broadbent L, Sharma P, Bamford CGG, et al.
Journal of Medical Virology. 97(11):e70713. doi:10.1002/jmv.70713
2025
Combining analysis of individual and wastewater whole genome sequencing improves SARS-CoV-2 surveillance.
Troendle EP, Lee AJ, Reyne MI, Allen DM, et al., Bamford CGG, Simpson DA.
Water Research. 284:123953. doi:10.1016/j.watres.2025.123953
2025
ISG15-dependent stabilisation of USP18 is necessary but not sufficient to regulate type I interferon signalling in humans.
Vasou A, Nightingale K, Cetkovská V, Scheler J, Bamford CGG, et al., Hughes DJ.
European Journal of Immunology. 55(2):e202451651. doi:10.1002/eji.202451651
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Find us in Belfast

We are based in the School of Biological Sciences at Queen's University Belfast, one of the UK and Ireland's leading research universities, in the heart of a friendly, affordable and creative city.

  • University Queen's University Belfast
  • School Biological Sciences
  • Institute Global Food Security
  • City Belfast, Northern Ireland

An open lab

Good science needs different minds, and we welcome people of every background, nationality, ethnicity, gender identity, sexual orientation, religion, age and disability status. Positions are advertised openly, everyone gets proper mentoring, and we work with people who have caring responsibilities or health conditions to find arrangements that fit.

If you are not sure whether you would fit, please get in touch.

Athena Swan Gender Charter, Gold Award

The Bamford Lab sits within the School of Biological Sciences at Queen's University Belfast, which holds an Athena Swan Gold award in recognition of its work on gender equality, and was the first School of Biology in the UK to reach that level.

Come and do a PhD, project or postdoc with us

We welcome curious, motivated people at every stage. If our questions excite you, get in touch, even just to chat about possibilities.

For prospective students

Opportunities come up at every stage, from undergraduate projects through PhDs to postdoctoral posts. We are always glad to hear from people who have their own funding, or who are looking for help to apply for it. Tell us a little about yourself and what you would like to work on, and we will point you to the routes and the next steps.

Email to enquire

Contact

Email c.bamford@qub.ac.uk
Post School of Biological Sciences, QUB, 19 Chlorine Gardens, Belfast BT9 5DL